Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.

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Version: Final published version
License: CC BY 4.0
Serval ID
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Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.
Journal
Psychiatry research
Author(s)
Martin E., Schoeler T., Pingault J.B., Barkhuizen W.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
07/2023
Peer-reviewed
Oui
Volume
325
Pages
115218
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Loneliness is a common, yet distressing experience associated with adverse outcomes including substance use problems and psychiatric disorders. To what extent these associations reflect genetic correlations and causal relationships is currently unclear. We applied Genomic Structural Equation Modelling (GSEM) to dissect the genetic architecture between loneliness and psychiatric-behavioural traits. Included were summary statistics from 12 genome-wide association analyses, including loneliness and 11 psychiatric phenotypes (range N: 9,537 - 807,553). We first modelled latent genetic factors amongst the psychiatric traits to then investigate potential causal effects between loneliness and the identified latent factors, using multivariate genome-wide association analyses and bidirectional Mendelian randomization. We identified three latent genetic factors, encompassing neurodevelopmental/mood conditions, substance use traits and disorders with psychotic features. GSEM provided evidence of a unique association between loneliness and the neurodevelopmental/mood conditions latent factor. Mendelian randomization results were suggestive of bidirectional causal effects between loneliness and the neurodevelopmental/mood conditions factor. These results imply that a genetic predisposition to loneliness may elevate the risk of neurodevelopmental/mood conditions, and vice versa. However, results may reflect the difficulty of distiguishing between loneliness and neurodevelopmental/mood conditions, which present in similar ways. We suggest, overall, the importance of addressing loneliness in mental health prevention and policy.
Keywords
Humans, Genome-Wide Association Study, Loneliness, Mental Disorders/epidemiology, Mental Disorders/genetics, Phenotype, Substance-Related Disorders/epidemiology, Substance-Related Disorders/genetics, Polymorphism, Single Nucleotide, Depression, Genetics, Genomic structural equation modelling, Mendelian randomization, Neurodevelopmental disorders, Mood disorders
Pubmed
Web of science
Open Access
Yes
Create date
15/05/2023 14:54
Last modification date
08/08/2024 7:42
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