New insights into the mechanisms of organ-specific breast cancer metastasis.

Details

Serval ID
serval:BIB_EEAEF22D8022
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New insights into the mechanisms of organ-specific breast cancer metastasis.
Journal
Seminars in Cancer Biology
Author(s)
Lorusso G., Rüegg C.
ISSN
1096-3650 (Electronic)
ISSN-L
1044-579X
Publication state
Published
Issued date
2012
Volume
22
Number
3
Pages
226-233
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Despite the substantial advances obtained in the treatment of localized malignancies, metastatic disease still lacks effective treatment and remains the primary cause of cancer mortality, including in breast cancer. Thus, in order to improve the survival of cancer patients it is necessary to effectively improve prevention or treatment of metastasis. To achieve this goal, complementary strategies can be envisaged: the first one is the eradication of established metastases by adding novel modalities to current treatments, such as immunotherapy or targeted therapies. A second one is to prevent tumor cell dissemination to secondary organs by targeting specific steps governing the metastatic cascade and organ-specific tropism. A third one is to block the colonization of secondary organs and subsequent cancer cell growth by impinging on the ability of disseminated cancer cells to adapt to the novel microenvironment. To obtain optimal results it might be necessary to combine these strategies. The development of therapeutic approaches aimed at preventing dissemination and organ colonization requires a deeper understanding of the specific genetic events occurring in cancer cells and of the host responses that co-operate to promote metastasis formation. Recent developments in the field disclosed novel mechanisms of metastasis. In particular the crosstalk between disseminated cancer cells and the host microenvironment is emerging as a critical determinant of metastasis. The identification of tissue-specific signals involved in metastatic progression will open the way to new therapeutic strategies. Here, we will review recent progress in the field, with particular emphasis on the mechanisms of organ specific dissemination and colonization of breast cancer.
Keywords
Breast Neoplasms/genetics, Breast Neoplasms/pathology, Cell Transformation, Neoplastic/genetics, Cell Transformation, Neoplastic/metabolism, Disease Progression, Gene Expression, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Metastasis/genetics, Neoplasm Metastasis/pathology, Neoplastic Cells, Circulating/pathology, Tumor Microenvironment/physiology
Pubmed
Web of science
Create date
10/01/2013 15:15
Last modification date
20/08/2019 17:16
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