Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity.

Details

Serval ID
serval:BIB_EEA1B5397CAF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity.
Journal
Frontiers in physiology
Author(s)
Rousseau A.S., Murdaca J., Le Menn G., Sibille B., Wahli W., Le Garf S., Chinetti G., Neels J.G., Mothe-Satney I.
ISSN
1664-042X (Print)
ISSN-L
1664-042X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
12
Pages
587753
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4 <sup>+</sup> T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (SKM) regeneration and mass maintenance. In this study, we showed that a deletion of a FAO modulator, peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), specifically in T cells (KO-T PPARβ/δ), increased the number of CD4 <sup>+</sup> T cells at day 2 following a cardiotoxin-induced SKM regeneration. Older KO-T PPARβ/δ mice maintained a Tregs prevalence in lymph nodes similar to young mice. Surprisingly, KO-T PPARβ/δ mice were protected from the effects of age on lean and fat mass and endurance capacity. Our results lead us to propose an original potential role of T cell metabolism in the effects of aging on the maintenance of body composition and endurance capacity.
Keywords
aging, immunometabolism, physical capacity, regulatory T cells, skeletal muscle
Pubmed
Web of science
Open Access
Yes
Create date
13/04/2021 14:39
Last modification date
28/05/2021 6:36
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