Lymphographic-Like Technique for the Treatment of Microcystic Lymphatic Malformation Components of <3 mm.

Details

Serval ID
serval:BIB_EE909A9324F5
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Lymphographic-Like Technique for the Treatment of Microcystic Lymphatic Malformation Components of <3 mm.
Journal
AJNR. American journal of neuroradiology
Author(s)
Da Ros V., Iacobucci M., Puccinelli F., Spelle L., Saliou G.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
39
Number
2
Pages
350-354
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The treatment of microcystic lymphatic malformations remains challenging. Our aim was to describe the lymphographic-like technique, a new technique of slow bleomycin infusion for the treatment of microcyst components of <3 mm, performed at our institution.
A retrospective analysis of a prospectively collected lymphatic malformation data base was performed. Patients with at least 1 microcystic lymphatic malformation component demonstrated on MR imaging treated by lymphographic-like technique bleomycin infusion were included in the study. Patient interviews and MR imaging were performed to assess subjective and objective (microcystic lymphatic malformation size decrease of >30%) clinical improvement, respectively. Patients were reviewed 3 months after each sclerotherapy session. Lymphographic-like technique safety and efficacy were assessed.
Between January 2012 and July 2016, sixteen patients (5 males, 11 females; mean age, 15 years; range, 1-47 years) underwent the bleomycin lymphographic-like technique for microcystic lymphatic malformations. Sixty sclerotherapy sessions were performed, with a mean of 4 sessions per patient (range, 1-8 sessions) and a mean follow-up of 26 months (range, 5-58 months). We observed no major and 3 minor complications: 1 eyelid infection, 1 case of severe postprocedural nausea and vomiting, and 1 case of skin discoloration. One patient was lost to follow-up. Overall MR imaging objective improvement was observed in 5/16 (31%) patients; overall improvement of clinical symptoms was obtained in 93% of treated patients.
The bleomycin lymphographic-like technique for microcystic lymphatic malformations is safe and feasible with objective improvement in about one-third of patients. MR signal intensity changes after the lymphographic-like technique are associated with subjective improvement of the patient's symptoms.
Keywords
Adolescent, Adult, Bleomycin/therapeutic use, Child, Child, Preschool, Female, Fluoroscopy/methods, Humans, Infant, Lymphatic Abnormalities/pathology, Lymphatic Abnormalities/therapy, Male, Middle Aged, Retrospective Studies, Sclerotherapy/methods, Therapy, Computer-Assisted/methods, Treatment Outcome, Young Adult
Pubmed
Web of science
Create date
05/12/2017 11:06
Last modification date
20/08/2019 17:16
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