The genome sequence of taurine cattle: a window to ruminant biology and evolution.
Details
Serval ID
serval:BIB_EE8C1C9D9ECA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The genome sequence of taurine cattle: a window to ruminant biology and evolution.
Journal
Science
Working group(s)
Analysis Consortium
ISSN
1095-9203[electronic], 0036-8075[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
324
Number
5926
Pages
522-528
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Keywords
Alternative Splicing, Animals, Animals, Domestic, Cattle, Evolution, Evolution, Molecular, Female, Genetic Variation, Genome, Humans, Male, MicroRNAs/genetics, Molecular Sequence Data, Proteins/genetics, Sequence Analysis, DNA, Species Specificity, Synteny
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2010 15:59
Last modification date
20/08/2019 16:16