Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort
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State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_EE818EC10B69
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort
Director(s)
Nydegger Andreas
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2022
Language
english
Abstract
Introduction: Given the lack of data, we aimed to assess the impact of the length of diagnostic delay on the natural his- tory of ulcerative colitis (UC) in pediatric (diagnosed <18 years) and adult patients (diagnosed ≥18 years). Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Diagnostic delay was defined as the interval between the first appearance of UC-related symp- toms until diagnosis. Logistic regression modeling evaluat- ed the appearance of the following complications in the long term according to the length of diagnostic delay: co- lonic dysplasia, colorectal cancer, UC-related hospitalization, colectomy, and extraintestinal manifestations (EIMs). Re- sults: A total of 184 pediatric and 846 adult patients were included. The median diagnostic delay was 4 [IQR 2–7.5] months for the pediatric-onset group and 3 [IQR 2–10] months for the adult-onset group (p = 0.873). In both, pedi- atric- and adult-onset groups, the length of diagnostic delay at UC diagnosis was not associated with colectomy, UC-re- lated hospitalization, colon dysplasia, and colorectal cancer. EIMs were significantly more prevalent at UC diagnosis in the adult-onset group with long diagnostic delay than in the adult-onset group with short diagnostic delay (p = 0.022). In the long term, the length of diagnostic delay was associated in the adult-onset group with colorectal dysplasia (p = 0.023), EIMs (p < 0.001), and more specifically arthritis/arthralgias.
Create date
01/11/2022 12:47
Last modification date
09/11/2022 8:15