Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort

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Serval ID
serval:BIB_EE818EC10B69
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Impact of Diagnostic Delay on Disease Course in Pediatric- versus Adult-Onset Patients with Ulcerative Colitis: Data from the Swiss IBD Cohort
Author(s)
Tran Vu Dang Chau
Director(s)
Nydegger Andreas
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2022
Language
english
Abstract
Introduction: Given the lack of data, we aimed to assess the impact of the length of diagnostic delay on the natural his- tory of ulcerative colitis (UC) in pediatric (diagnosed <18 years) and adult patients (diagnosed ≥18 years). Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Diagnostic delay was defined as the interval between the first appearance of UC-related symp- toms until diagnosis. Logistic regression modeling evaluat- ed the appearance of the following complications in the long term according to the length of diagnostic delay: co- lonic dysplasia, colorectal cancer, UC-related hospitalization, colectomy, and extraintestinal manifestations (EIMs). Re- sults: A total of 184 pediatric and 846 adult patients were included. The median diagnostic delay was 4 [IQR 2–7.5] months for the pediatric-onset group and 3 [IQR 2–10] months for the adult-onset group (p = 0.873). In both, pedi- atric- and adult-onset groups, the length of diagnostic delay at UC diagnosis was not associated with colectomy, UC-re- lated hospitalization, colon dysplasia, and colorectal cancer. EIMs were significantly more prevalent at UC diagnosis in the adult-onset group with long diagnostic delay than in the adult-onset group with short diagnostic delay (p = 0.022). In the long term, the length of diagnostic delay was associated in the adult-onset group with colorectal dysplasia (p = 0.023), EIMs (p < 0.001), and more specifically arthritis/arthralgias.
Create date
01/11/2022 12:47
Last modification date
09/11/2022 8:15
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