Digitoxin metabolism by rat liver microsomes.

Details

Ressource 1Download: BIB_EE7D4CC5FB04.P001.pdf (556.51 [Ko])
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_EE7D4CC5FB04
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Digitoxin metabolism by rat liver microsomes.
Journal
Biochemical pharmacology
Author(s)
Schmoldt A., Benthe H.F., Haberland G.
ISSN
1873-2968 (Electronic)
ISSN-L
0006-2952
Publication state
Published
Issued date
01/09/1975
Peer-reviewed
Oui
Volume
24
Number
17
Pages
1639-1641
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs.
Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Methods: PubMed and Google Scholar search. All articles from January 2004 until November 2014 were identified. Reference lists of relevant articles were also manually searched.
Results: Ten studies on LOS and nine studies on costs were reviewed. The methods used to assess
malnutrition and to calculate costs differed considerably between studies. Malnutrition led to an
increased LOS ranging from 2.4 to 7.2 days. Among hospitalized patients, malnutrition led to an additional individual cost ranging between 1640 V and 5829 V. At the national level, the costs of malnutrition ranged between 32.8 million V and 1.2 billion V. Expressed as percentage of national health expenditures, the values ranged between 2.1% and 10%.
Conclusions: In Europe, malnutrition leads to an increase in LOS and in hospital costs, both at the individual and the national level. Standardization of methods and results reported is needed to adequately
compare results between countries.
© 2015 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights
reserved.
Keywords
Animals, Chromatography, Thin Layer, Digitoxigenin/metabolism, Digitoxin/metabolism, Hydroxylation, In Vitro Techniques, Male, Microsomes, Liver/metabolism, NADP/metabolism, Rats, Time Factors
Open Access
Yes
Create date
10/02/2016 15:07
Last modification date
11/02/2020 6:19
Usage data