Impact of Nedd4 proteins and serum and glucocorticoid-induced kinases on epithelial Na+ transport in the distal nephron
Details
Serval ID
serval:BIB_EE7BA4F82208
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Impact of Nedd4 proteins and serum and glucocorticoid-induced kinases on epithelial Na+ transport in the distal nephron
Journal
Journal of the American Society of Nephrology
ISSN
1046-6673 (Print)
Publication state
Published
Issued date
11/2005
Volume
16
Number
11
Pages
3167-74
Notes
Journal Article
Review --- Old month value: Nov
Review --- Old month value: Nov
Abstract
The precise control of BP occurs via Na(+) homeostasis and involves the precise regulation of the epithelial Na(+) channel (ENaC) in the aldosterone-sensitive distal nephron. This has been corroborated by the linkage of mutations in the genes encoding ENaC subunits and Liddle's syndrome, a heritable form of human hypertension. Mapping of these mutations on ENaC indicated that inactivation of PY motifs is responsible and leads to the proposition that the channel interacts via its PY motifs with the WW domains of the Nedd4/Nedd4-like ubiquitin-protein ligase family. It is now well established that the cell surface expression of ENaC is controlled via ubiquitylation by this protein family and that this ubiquitylation is regulated by the aldosterone-induced protein serum and glucocorticoid induced kinase 1.
Keywords
Blood Pressure/*physiology
Epithelial Sodium Channel
Glucocorticoids/physiology
Homeostasis
Humans
Kidney Diseases/genetics
Nephrons/*physiology
Sodium/metabolism
Sodium Channels/genetics/physiology
Ubiquitin/metabolism
Ubiquitin-Protein Ligases/*physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:03
Last modification date
20/08/2019 17:16