Fish oil supplementation does not alter energy efficiency in healthy males

Details

Serval ID
serval:BIB_EE70EEEE1227
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fish oil supplementation does not alter energy efficiency in healthy males
Journal
Clinical Nutrition
Author(s)
Bortolotti  M., Tappy  L., Schneiter  P.
ISSN
0261-5614 (Print)
Publication state
Published
Issued date
04/2007
Volume
26
Number
2
Pages
225-30
Language
english
Notes
Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
BACKGROUND AND AIMS: Fish oil (FO) supplementation prevents the development of obesity and insulin resistance, and upregulate the expression of UCP3 in skeletal muscle in rodents. This may represent indirect evidence that FO promotes fat oxidation and/or alter energy efficiency. The aim of this study was to evaluate whether such effects can be observed in humans. The metabolic effects of FO were assessed during exercise in order to obtain a direct measurement of energy efficiency. METHODS: Eight healthy male volunteers were studied with and without supplementation with 7.2 g/day FO (including 1.1 g/day eicosopentaenoic acid and 0.7 g/day decosahexaenoic acid) during 14 days. Their VO(2 max) was measured on cycle ergometer. Thereafter, energy metabolism (substrate oxidation, energy expenditure and energy efficiency) was assessed during a 30 min cycling exercise at 50% VO(2 max) performed 2 h 30 after a standardized, high carbohydrate breakfast. RESULTS: VO(2 max) was 38.6+/-2.2 after FO and 38.4+/-2.0 (mL x kg(-1) x min(-1)) in control conditions (NS). Basal plasma glucose, insulin and NEFA concentrations, and energy metabolism were similar with FO and in controls. During exercise, the increases in plasma NEFA concentrations, energy expenditure, glucose and lipid oxidation, and the decreases in glycaemia and insulinemia were not altered by FO intake. Energy efficiency was 22.4+/-0.6% after FO vs 21.8+/-0.7% in controls. In order to ascertain that the absence of effects of FO was not due to consumption of a carbohydrate meal immediately before exercise, 4 of the 8 subjects were re-studied in fasting conditions, FO also failed to alter energy efficiency in this subset of studies. CONCLUSION: FO supplementation did not significantly alter energy metabolism and energy efficiency during exercise in healthy humans.
Keywords
Adult Basal Metabolism/*drug effects/physiology Bicycling/physiology Blood Glucose/*metabolism Cross-Over Studies Dietary Supplements Energy Metabolism/*drug effects/physiology Exercise/*physiology Fatty Acids, Nonesterified/blood Fish Oils/*administration & dosage Humans Insulin/blood Lipid Peroxidation/drug effects Male Oxidation-Reduction Oxygen Consumption
Pubmed
Web of science
Create date
24/01/2008 14:36
Last modification date
20/08/2019 17:16
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