Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study.

Details

Serval ID
serval:BIB_EE2BF9BF9379
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study.
Journal
Rheumatology international
Author(s)
Coattrenec Y., Muller Y.D., Spoerl D., Lobrinus J.A., Seebach J.D.
ISSN
1437-160X (Electronic)
ISSN-L
0172-8172
Publication state
Published
Issued date
12/2021
Volume
41
Number
12
Pages
2147-2156
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
ANCA-associated vasculitis (AAV) in general involves small blood vessels and includes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA). Although reported in a few studies, the prevalence of large vessel vasculitis (LVV) in patients with AAV remains to be further explored. The goal of the present study was to assess the prevalence of LVV in a cohort of patients with AAV and to characterize this population. We conducted a ten-year retrospective study of a single-center cohort of AAV, including 101 patients with GPA (n = 58), EGPA (n = 28), MPA (n = 15), and compared the groups with or without associated LVV. LVV was diagnosed in five patients, two with aortitis and three with temporal arteritis, corresponding to a total prevalence of 5.0% [95% CI 1.6-11.2%]. This value was significantly higher than the estimated prevalence of LVV in the normal Swiss population (OR 234.9 95% CI 91.18-605.2, p < 0.001). All five patients had GPA, whereas no cases with EGPA or MPA were identified. Anti-PR3 antibodies were detected in four out of five patients, anti-MPO in one patient. Since LVV can occur in a significant proportion of patients with GPA, evaluation for LVV may be considered systematically in the diagnostic workup of AAV.
Keywords
Aged, Aged, 80 and over, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/classification, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology, Antibodies, Antineutrophil Cytoplasmic/immunology, Female, Giant Cell Arteritis/complications, Humans, Male, Middle Aged, Retrospective Studies, ANCA-associated vasculitis, Antineutrophil cytoplasmic antibodies, Aortitis, Eosinophilic granulomatosis with polyangiitis, Granulomatosis with polyangiitis, Large vessel vasculitis, Microscopic polyangiitis, Temporal arteritis
Pubmed
Web of science
Open Access
Yes
Create date
01/10/2021 17:32
Last modification date
12/08/2022 6:40
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