Hypofractionated radiotherapy in pancreatic cancer: Lessons from the past in the era of stereotactic body radiation therapy.

Details

Serval ID
serval:BIB_EE057E94F72E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hypofractionated radiotherapy in pancreatic cancer: Lessons from the past in the era of stereotactic body radiation therapy.
Journal
Critical reviews in oncology/hematology
Author(s)
De Bari B., Porta L., Mazzola R., Alongi F., Wagner A.D., Schäfer M., Bourhis J., Ozsahin M.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
103
Pages
49-61
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The role of neoadjuvant and definitive radiotherapy combined or not to chemotherapy in the therapeutic approach to pancreatic cancer has not been yet elucidated. There is some evidence in favour of neoadjuvant local and/or systemic approaches that enable surgical resection in patients initially considered to be "borderline resectable". Nevertheless, most of these studies have been conducted using schedules of radiotherapy (treatment volumes, total doses, dose/fraction) that are nowadays considered not efficient enough and/or too toxic. Recently, stereotactic body radiation therapy (SBRT) has been proposed as a new therapeutic option for pancreatic cancer, both in the neoadjuvant and in the definitive setting. The aim of this study is to review the radiobiological and clinical evidences supporting hypofractionation in pancreatic cancer. Moreover, we performed an extensive review of available clinical and dosimetric data on SBRT in pancreatic cancer.

Keywords
Humans, Neoadjuvant Therapy, Pancreatic Neoplasms/radiotherapy, Radiosurgery/adverse effects, Treatment Outcome
Pubmed
Create date
14/06/2016 16:17
Last modification date
20/08/2019 16:15
Usage data