[Quorum sensing: a new clinical target for Pseudomonas aeruginosa?]

Details

Serval ID
serval:BIB_EE0269ACE2BF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
[Quorum sensing: a new clinical target for Pseudomonas aeruginosa?]
Journal
Med Mal Infect
Author(s)
Le Berre R., Faure K., Nguyen S., Pierre M., Ader F., Guery B.
ISSN
0399-077X (Print)
ISSN-L
0399-077X
Publication state
Published
Issued date
07/2006
Volume
36
Number
7
Pages
349-57
Language
french
Notes
Le Berre, R
Faure, K
Nguyen, S
Pierre, M
Ader, F
Guery, B
fre
Review
France
Med Mal Infect. 2006 Jul;36(7):349-57. doi: 10.1016/j.medmal.2006.01.008. Epub 2006 May 2.
Abstract
Pseudomonas aeruginosa is an opportunistic bacteria causing a wide variety of infections. The bacterial virulence depends on a large panel of cell-associated and extracellular factors. Quorum sensing (QS) allows cell-to-cell communication: sensing the environment, this system coordinates the expression of various genes within the bacterial population. QS is based on an interaction between a small diffusible molecule, an acylhomoserine lactone (AHL), and a transcriptionnal activator. Two QS systems, the las and rhl systems, have been identified in P. aeruginosa. The las system associates the transcriptionnal activator protein LasR and LasI responsible for the synthesis of a specific AHL: C12-HSL. This system was shown to activate the expression of a large number of virulence factors. Similarly, the rhl system associates the transcriptionnal activator protein RhlR with RhlI, which is responsible for the synthesis of another AHL: C4-HSL. Synthesis and secretion of a number of virulence factors are controlled by QS. Utilization of different animals models showed the crucial role of QS in the pathogenesis of P. aeruginosa infections. The discovery of QS has given a new opportunity to treat bacterial infection by another means than growth inhibition. New drugs inhibiting QS were recently discovered: furanone compounds can repress a large number of QS-regulated genes, including numerous P. aeruginosa virulence factor genes. Furanone administration to mice infected with P. aeruginosa significantly reduced lung bacterial load compared with the control group.
Keywords
Cell Communication, Homoserine/*analogs & derivatives/metabolism/physiology, Lactones/metabolism, Polymorphism, Genetic, Pseudomonas aeruginosa/genetics/*pathogenicity
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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