Permanently reduced plasma ionized magnesium among renal transplant recipients on cyclosporine
Details
Serval ID
serval:BIB_EDD84F50C161
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Permanently reduced plasma ionized magnesium among renal transplant recipients on cyclosporine
Journal
Transplant International
ISSN
0934-0874 (Print)
Publication state
Published
Issued date
1999
Volume
12
Number
4
Pages
244-9
Notes
Comparative Study
Journal Article
Journal Article
Abstract
Hypomagnesemia is common after kidney transplantation. Until recently, only the determination of total plasma magnesium was possible, whereas the assessment of ionized magnesium has since become practicable. One hundred and nine renal transplant patients on cyclosporine with allografts functioning stably for more than 6 months and plasma creatinine levels of less than 200 micromol/l entered the study. Total and ionized circulating magnesium were assessed among these 109 patients, as well as among 15 renal transplant patients not on cyclosporine and 21 healthy volunteers. Cyclosporine patients showed significantly lower total and ionized circulating magnesium values than the two control groups. Plasma total and ionized magnesium levels were also significantly lower among cyclosporine patients treated concurrently with insulin or oral hypoglycemic agents than among those who were not. No correlation was noted between time after transplantation and plasma magnesium with respect to patients on cyclosporine. In conclusion, the study demonstrates that a large subset of renal transplant patients treated with cyclosporine have permanent deficiencies of ionized and total magnesium. The tendency towards hypomagnesemia is also more pronounced among patients with diabetes mellitus.
Keywords
Adolescent
Adult
Aged
Azathioprine/therapeutic use
Cardiovascular Agents/therapeutic use
Child
Cyclosporine/*therapeutic use
Diuretics/therapeutic use
Female
Follow-Up Studies
Humans
Hypoglycemic Agents/therapeutic use
Immunosuppressive Agents/*therapeutic use
Kidney Transplantation/immunology/*physiology
Magnesium/*blood
Male
Middle Aged
Mycophenolic Acid/analogs & derivatives/therapeutic use
Prednisone/therapeutic use
Reference Values
Pubmed
Web of science
Create date
28/01/2008 14:50
Last modification date
20/08/2019 17:15