Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

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Version: author
Serval ID
serval:BIB_EDCDBEB719B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.
Journal
International Journal of Epidemiology
Author(s)
Gaudet Mia M., Olshan Andrew F., Chuang Shu-Chun, Berthiller Julien, Zhang Zuo-Feng, Lissowska Jolanta, Zaridze David, Winn Deborah M., Wei Qingyi, Talamini Renato, Szeszenia-Dabrowska Neonilia, Sturgis Erich M., Schwartz Stephen M., Rudnai Peter, Eluf-Neto Jose, Muscat Joshua, Morgenstern Hal, Menezes Ana, Matos Elena, Bucur Alexandru, Levi Fabio, Lazarus Philip, La Vecchia Carlo, Koifman Sergio, Kelsey Karl, Herrero Rolando, Hayes Richard B., Franceschi Silvia, Wünsch-Filho Victor, Fernandez Leticia, Fabianova Eleonora, Daudt Alexander W., Dal Maso Luigino, Curado Maria Paula, Chen Chu, Castellsague Xavier, Benhamou Simone, Boffetta Paolo, Brennan Paul, Hashibe Mia
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
39
Number
4
Pages
1091-1102
Language
english
Notes
licence nationale
Abstract
BACKGROUND: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. METHODS: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. RESULTS: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) 25.0-30.0 kg/m(2) (0.52, 0.44-0.60) and BMI >/=30 kg/m(2) (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m(2). These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI 25 kg/m(2) was present only in smokers and drinkers. CONCLUSIONS: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.
Pubmed
Web of science
Open Access
Yes
Create date
24/11/2010 10:38
Last modification date
20/08/2019 17:15
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