Conversion of supraventricular arrhythmias to sinus rhythm using flecainide

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Serval ID
serval:BIB_ED54D6CCED50
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Conversion of supraventricular arrhythmias to sinus rhythm using flecainide
Journal
European Heart Journal
Author(s)
Goy J. J., Grbic M., Hurni M., Finci L., Maendly R., Duc J., Sigwart U.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
06/1985
Volume
6
Number
6
Pages
518-24
Language
english
Notes
Journal Article --- Old month value: Jun
Abstract
We evaluated the efficacy of flecainide acetate (given intravenously to a maximal dose of 2 mg kg-1 and then orally in a dose of 100 mg b.d. or 100 mg t.d.s.) in the conversion to sinus rhythm of 50 patients exhibiting supraventricular arrhythmias (39 with atrial fibrillation, 6 with atrial flutter, 4 with supraventricular tachycardia and one with supraventricular tachycardia in association with the Wolff-Parkinson-White syndrome). Conversion was achieved in 36 patients (72%) (29 cases with atrial fibrillation, 4 cases with supraventricular tachycardia, 2 cases with atrial flutter and one case with Wolff-Parkinson-White syndrome), over a mean period of 7.4 +/- 9 h. The patients in which conversion was achieved had arrhythmias which had been in existence for a shorter time (5.3 +/- 9.8 days) than those in which conversion was not achieved (16.7 +/- 26.2 days) (P less than 0.01). The mean dosage of flecainide used to achieve conversion was 2.5 +/- 2.36 mg kg-1. Flecainide appears to be an effective agent for the conversion to sinus rhythm of atrial fibrillation and supraventricular tachycardias. Its efficacy in cases of atrial flutter has not yet been demonstrated.
Keywords
Adult Aged Anti-Arrhythmia Agents/*therapeutic use Arrhythmia/*drug therapy/etiology/physiopathology Female Flecainide Heart Rate Humans Male Middle Aged Piperidines/administration & dosage/adverse effects/*therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 10:24
Last modification date
01/10/2019 7:20
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