TLR3 deficiency in patients with herpes simplex encephalitis.

Details

Serval ID
serval:BIB_ED3AFF47EDB9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
TLR3 deficiency in patients with herpes simplex encephalitis.
Journal
Science
Author(s)
Zhang S.Y., Jouanguy E., Ugolini S., Smahi A., Elain G., Romero P., Segal D., Sancho-Shimizu V., Lorenzo L., Puel A., Picard C., Chapgier A., Plancoulaine S., Titeux M., Cognet C., von Bernuth H., Ku C.L., Casrouge A., Zhang X.X., Barreiro L., Leonard J., Hamilton C., Lebon P., Héron B., Vallée L., Quintana-Murci L., Hovnanian A., Rozenberg F., Vivier E., Geissmann F., Tardieu M., Abel L., Casanova J.L.
ISSN
1095-9203[electronic]
Publication state
Published
Issued date
2007
Volume
317
Number
5844
Pages
1522-1527
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis. TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
Keywords
Alleles, CD8-Positive T-Lymphocytes/immunology, Cell Line, Child, Preschool, Dendritic Cells/immunology, Encephalitis, Herpes Simplex/genetics, Encephalitis, Herpes Simplex/immunology, Female, Fibroblasts/immunology, Fibroblasts/metabolism, Genes, Dominant, Herpesvirus 1, Human/physiology, Heterozygote, Humans, Immunity, Innate, Infant, Interferons/biosynthesis, Keratinocytes/immunology, Killer Cells, Natural/immunology, Leukocytes, Mononuclear/immunology, Mutation, Poly I-C/pharmacology, Toll-Like Receptor 3/chemistry, Toll-Like Receptor 3/deficiency
Pubmed
Web of science
Create date
28/01/2008 11:27
Last modification date
20/08/2019 16:15
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