Cartilage can be thicker in advanced osteoarthritic knees: a tridimensional quantitative analysis of cartilage thickness at posterior aspect of femoral condyles.

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Version: Final published version
Serval ID
serval:BIB_ED2A1866F28E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cartilage can be thicker in advanced osteoarthritic knees: a tridimensional quantitative analysis of cartilage thickness at posterior aspect of femoral condyles.
Journal
The British journal of radiology
Author(s)
Omoumi P., Babel H., Jolles B.M., Favre J.
ISSN
1748-880X (Electronic)
ISSN-L
0007-1285
Publication state
Published
Issued date
07/2018
Peer-reviewed
Oui
Volume
91
Number
1087
Pages
20170729
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To test, through tridimensional analysis, whether (1) cartilage thickness at the posterior aspect of femoral condyles differs in knees with medial femorotibial osteoarthritis (OA) compared to non-OA knees; (2) the location of the thickest cartilage at the posterior aspect of femoral condyles differs between OA and non-OA knees.
CT arthrograms of knees without radiographic OA (n = 30) and with severe medial femorotibial OA (n = 30) were selected retrospectively from patients over 50 years of age. The groups did not differ in gender, age and femoral size. CT arthrograms were segmented to measure the mean cartilage thickness, the maximal cartilage thickness and its location in a region of interest at the posterior aspect of condyles.
For the medial condyle, mean and maximum cartilage thicknesses were statistically significantly higher in OA knees compared to non-OA knees [1.66 vs 1.46 mm (p = 0.03) and 2.56 vs 2.14 mm (p = 0.003), respectively]. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle for both groups, without significant difference between groups. For the lateral condyle, no statistically significant difference between non-OA and OA knees was found (p ≥ 0.17).
Cartilage at the posterior aspect of the medial condyle, but not the lateral condyle, is statistically significantly thicker in advanced medial femorotibial OA knees compared to non-OA knees. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage. Advances in knowledge: This study, through a quantitative tridimensional approach, shows that cartilage at the posterior aspect of the medial condyles is thicker in severe femorotibial osteoarthritic knees compared to non-OA knees. In the posterior aspect of the medial condyle, the thickest cartilage is located in the vicinity of the center of the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage.
Keywords
Arthrography/methods, Cartilage, Articular/diagnostic imaging, Cartilage, Articular/pathology, Female, Femur/diagnostic imaging, Humans, Knee Joint/diagnostic imaging, Knee Joint/pathology, Male, Middle Aged, Osteoarthritis, Knee/diagnostic imaging, Osteoarthritis, Knee/pathology, Radiographic Image Interpretation, Computer-Assisted, Retrospective Studies, Tomography, X-Ray Computed
Pubmed
Web of science
Open Access
Yes
Create date
12/04/2018 18:54
Last modification date
20/08/2019 17:15
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