Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding.
Details
Serval ID
serval:BIB_ECE7ED46C672
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding.
Journal
British Journal of Haematology
ISSN
1365-2141 (Electronic)
ISSN-L
0007-1048
Publication state
Published
Issued date
2008
Volume
140
Number
5
Pages
572-577
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: short report
Abstract
A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.
Keywords
Child, Chromosome Aberrations, Chromosome Banding, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Karyotyping, Nucleic Acid Hybridization, Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
Pubmed
Web of science
Open Access
Yes
Create date
17/09/2011 10:03
Last modification date
20/08/2019 17:14
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