Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load.

Details

Ressource 1Download: serval:BIB_ECDBB0828042.P001 (218.72 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_ECDBB0828042
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load.
Journal
British Journal of Nutrition
Author(s)
Tran C., Jacot-Descombes D., Lecoultre V., Fielding B.A., Carrel G.,  K.A., Schneiter P., Bortolotti M., Frayn K.N., Tappy L.
ISSN
1475-2662 (Electronic)
ISSN-L
0007-1145
Publication state
Published
Issued date
2010
Volume
104
Number
8
Pages
1139-1147
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
The increase in VLDL TAG concentration after ingestion of a high-fructose diet is more pronounced in men than in pre-menopausal women. We hypothesised that this may be due to a lower fructose-induced stimulation of de novo lipogenesis (DNL) in pre-menopausal women. To evaluate this hypothesis, nine healthy male and nine healthy female subjects were studied after ingestion of oral loads of fructose enriched with 13C6 fructose. Incorporation of 13C into breath CO2, plasma glucose and plasma VLDL palmitate was monitored to evaluate total fructose oxidation, gluconeogenesis and hepatic DNL, respectively. Substrate oxidation was assessed by indirect calorimetry. After 13C fructose ingestion, 44.0 (sd 3.2)% of labelled carbons were recovered in plasma glucose in males v. 41.9 (sd 2.3)% in females (NS), and 42.9 (sd 3.7)% of labelled carbons were recovered in breath CO2 in males v. 43.0 (sd 4.5)% in females (NS), indicating similar gluconeogenesis from fructose and total fructose oxidation in males and females. The area under the curve for 13C VLDL palmitate tracer-to-tracee ratio was four times lower in females (P < 0.05), indicating a lower DNL. Furthermore, lipid oxidation was significantly suppressed in males (by 16.4 (sd 5.2), P < 0.05), but it was not suppressed in females ( -1.3 (sd 4.7)%). These results support the hypothesis that females may be protected against fructose-induced hypertriglyceridaemia because of a lower stimulation of DNL and a lower suppression of lipid oxidation.
Keywords
Administration, Oral, Adolescent, Adult, Blood Glucose/metabolism, Carbohydrate Metabolism, Carbon/metabolism, Carbon Isotopes, Female, Fructose/administration & dosage, Fructose/metabolism, Humans, Lipid Metabolism, Lipid Peroxidation, Male, Sex Characteristics, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
20/03/2011 18:03
Last modification date
25/09/2019 6:11
Usage data