Thalamus-related anomalies as candidate mechanism-based biomarkers for psychosis.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_ECBC2ABD31CF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Thalamus-related anomalies as candidate mechanism-based biomarkers for psychosis.
Journal
Schizophrenia research
Author(s)
Steullet P.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
226
Pages
147-157
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Identification of reliable biomarkers of prognosis in subjects with high risk to psychosis is an essential step to improve care and treatment of this population of help-seekers. Longitudinal studies highlight some clinical criteria, cognitive deficits, patterns of gray matter alterations and profiles of blood metabolites that provide some levels of prediction regarding the conversion to psychosis. Further effort is warranted to validate these results and implement these types of approaches in clinical settings. Such biomarkers may however fall short in entangling the biological mechanisms underlying the disease progression, an essential step in the development of novel therapies. Circuit-based approaches, which map on well-identified cerebral functions, could meet these needs. Converging evidence indicates that thalamus abnormalities are central to schizophrenia pathophysiology, contributing to clinical symptoms, cognitive and sensory deficits. This review highlights the various thalamus-related anomalies reported in individuals with genetic risks and in the different phases of the disorder, from prodromal to chronic stages. Several anomalies are potent endophenotypes, while others exist in clinical high-risk subjects and worsen in those who convert to full psychosis. Aberrant functional coupling between thalamus and cortex, low glutamate content and readouts from resting EEG carry predictive values for transition to psychosis or functional outcome. In this context, thalamus-related anomalies represent a valuable entry point to tackle circuit-based alterations associated with the emergence of psychosis. This review also proposes that longitudinal surveys of neuroimaging, EEG readouts associated with circuits encompassing the mediodorsal, pulvinar in high-risk individuals could unveil biological mechanisms contributing to this psychiatric disorder.
Keywords
Mediodorsal, Prodrome, Psychosis, Pulvinar, Thalamic reticular nucleus, Thalamus
Pubmed
Web of science
Open Access
Yes
Create date
06/06/2019 11:19
Last modification date
30/06/2021 6:34
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