Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures

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Ressource 1Download: serval:BIB_ECB9636949E3.P001 (80.11 [Ko])
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Serval ID
serval:BIB_ECB9636949E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures
Journal
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Author(s)
Ensrud K. E., Ewing S. K., Taylor B. C., Fink H. A., Stone K. L., Cauley J. A., Tracy J. K., Hochberg M. C., Rodondi N., Cawthon P. M.
ISSN
1079-5006 (Print)
Publication state
Published
Issued date
07/2007
Peer-reviewed
Oui
Volume
62
Number
7
Pages
744-51
Language
english
Notes
Journal Article Research Support, N.I.H., Extramural --- Old month value: Jul
Abstract
BACKGROUND: A standard phenotype of frailty was associated with an increased risk of adverse outcomes including mortality in a recent study of older adults. However, the predictive validity of this phenotype for fracture outcomes and across risk subgroups is uncertain. METHODS: To determine whether a standard frailty phenotype was independently associated with risk of adverse health outcomes in older women and to evaluate the consistency of associations across risk subgroups defined by age and body mass index (BMI), we ascertained frailty status in a cohort of 6724 women>or=69 years and followed them prospectively for incident falls, fractures, and mortality. Frailty was defined by the presence of three or more of the following criteria: unintentional weight loss, weakness, self-reported poor energy, slow walking speed, and low physical activity. Incident recurrent falls were defined as at least two falls during the subsequent year. Incident fractures (confirmed with x-ray reports), including hip fractures, and deaths were ascertained during an average of 9 years of follow-up. RESULTS: After controlling for multiple confounders such as age, health status, medical conditions, functional status, depressive symptoms, cognitive function, and bone mineral density, frail women were subsequently at increased risk of recurrent falls (multivariate odds ratio=1.38, 95% confidence interval [CI], 1.02-1.88), hip fracture (multivariate hazards ratio [MHR]=1.40, 95% CI, 1.03-1.90), any nonspine fracture (MHR=1.25, 95% CI, 1.05-1.49), and death (MHR=1.82, 95% CI, 1.56-2.13). The associations between frailty and these outcomes persisted among women>or=80 years. In addition, associations between frailty and an increased risk of falls, fracture, and mortality were consistently observed across categories of BMI, including BMI>or=30 kg/m2. CONCLUSION: Frailty is an independent predictor of adverse health outcomes in older women, including very elderly women and older obese women.
Keywords
*Accidental Falls Aged Aged, 80 and over Body Mass Index Female Follow-Up Studies *Fractures, Spontaneous *Frail Elderly Humans *Mortality Osteoporosis/*complications Phenotype Prospective Studies Recurrence
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 13:01
Last modification date
25/09/2019 7:11
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