Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Wan, C.; Bachmann, N.; Mitov, V.; Blanquart, F.; Céspedes, S.P.; Turk, T.; Neumann, K.; Beerenwinkel, N.; Bogojeska, J.; Fellay, J.; Roth, V.; Böni, J.; Perreau, M.; Klimkait, T.; Yerly, S.; Battegay, M.; Walti, L.; Calmy, A.; Vernazza, P.; Bernasconi, E.; Cavassini, M.; Metzner, K.J.; Günthard, H.F.; Kouyos, R.D.

doi:10.1038/s41467-020-19198-7

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Details

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State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_EC2E5183286F

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.

Journal

Nature communications

Author(s)

Wan C., Bachmann N., Mitov V., Blanquart F., Céspedes S.P., Turk T., Neumann K., Beerenwinkel N., Bogojeska J., Fellay J., Roth V., Böni J., Perreau M., Klimkait T., Yerly S., Battegay M., Walti L., Calmy A., Vernazza P., Bernasconi E., Cavassini M., Metzner K.J., Günthard H.F., Kouyos R.D.

Working group(s)

Swiss HIV Cohort Study

Contributor(s)

Anagnostopoulos A., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Günthard H.F., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Ledergerber B., Martinetti G., de Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Rudin C., Scherrer A.U., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Wandeler G., Weber R., Yerly S.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

02/11/2020

Peer-reviewed

Oui

Volume

Number

Pages

5542

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish

Abstract

The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. We use a unique nationwide cohort of 610 well-characterized HIV-1 subtype-B infected individuals on suppressive ART for a median of 5.4 years. We find that a moderate but significant fraction of the HIV-1 reservoir size 1.5 years after the initiation of ART is explained by genetic factors. At the same time, we find more tentative evidence for the heritability of the long-term HIV-1 reservoir decay. Our findings indicate that viral genetic factors contribute to the HIV-1 reservoir size and hence the infecting HIV-1 strain may affect individual patients' hurdle towards a cure.

Keywords

Adult, Anti-Retroviral Agents/pharmacology, CD4-Positive T-Lymphocytes/virology, Cohort Studies, DNA, Viral/genetics, Female, Genome, Viral, HIV Infections/virology, HIV-1/drug effects, HIV-1/genetics, Humans, Male, Time Factors, Viral Load

URN

urn:nbn:ch:serval-BIB_EC2E5183286F8

OAI-PMH

oai:serval.unil.ch:BIB_EC2E5183286F

DOI

10.1038/s41467-020-19198-7

Pubmed

33139735

Web of science

000617729900003

Open Access

Yes