Bundle myelin fraction (BMF) mapping of different white matter connections using microstructure informed tractography.

Details

Serval ID
serval:BIB_EC1185AC9286
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bundle myelin fraction (BMF) mapping of different white matter connections using microstructure informed tractography.
Journal
NeuroImage
Author(s)
Schiavi S., Lu P.J., Weigel M., Lutti A., Jones D.K., Kappos L., Granziera C., Daducci A.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
01/04/2022
Peer-reviewed
Oui
Volume
249
Pages
118922
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To date, we have scarce information about the relative myelination level of different fiber bundles in the human brain. Indirect evidence comes from postmortem histology data but histological stainings are unable to follow a specific bundle and determine its intrinsic myelination. In this context, quantitative MRI, and diffusion MRI tractography may offer a viable solution by providing, respectively, voxel-wise myelin sensitive maps and the pathways of the major tracts of the brain. Then, "tractometry" can be used to combine these two pieces of information by averaging tissue features (obtained from any voxel-wise map) along the streamlines recovered with diffusion tractography. Although this method has been widely used in the literature, in cases of voxels containing multiple fiber populations (each with different levels of myelination), tractometry provides biased results because the same value will be attributed to any bundle passing through the voxel. To overcome this bias, we propose a new method - named "myelin streamline decomposition" (MySD) - which extends convex optimization modeling for microstructure informed tractography (COMMIT) allowing the actual value measured by a microstructural map to be deconvolved on each individual streamline, thereby recovering unique bundle-specific myelin fractions (BMFs). We demonstrate the advantage of our method with respect to tractometry in well-studied bundles and compare the cortical projection of the obtained bundle-wise myelin values of both methods. We also prove the stability of our approach across different subjects and different MRI sensitive myelin mapping approaches. This work provides a proof-of-concept of in vivo investigations of entire neuronal pathways that, to date, are not possible.
Keywords
Adult, Diffusion Tensor Imaging/methods, Humans, Myelin Sheath, Nerve Net/anatomy & histology, Nerve Net/diagnostic imaging, Neural Pathways/anatomy & histology, Neural Pathways/diagnostic imaging, White Matter/anatomy & histology, White Matter/diagnostic imaging, Bundle-specific myelin content, Diffusion MRI, Human brain, Microstructure, Microstructure informed tractography, Myelin streamline decomposition, Tractography
Pubmed
Web of science
Open Access
Yes
Create date
31/01/2022 10:55
Last modification date
01/04/2022 5:34
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