Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_EC0CAB165489
Type
Article: article from journal or magazin.
Collection
Publications
Title
Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.
Journal
EMBO Molecular Medicine
Author(s)
Degueurce G., D'Errico I., Pich C., Ibberson M., Schütz F., Montagner A., Sgandurra M., Mury L., Jafari P., Boda A., Meunier J., Rezzonico R., Brembilla N.C., Hohl D., Kolios A., Hofbauer G., Xenarios I., Michalik L.
ISSN
1757-4684 (Electronic)
ISSN-L
1757-4676
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
8
Number
8
Pages
919-936
Language
english
Abstract
Although excessive exposure to UV is widely recognized as a major factor leading to skin perturbations and cancer, the complex mechanisms underlying inflammatory skin disorders resulting from UV exposure remain incompletely characterized. The nuclear hormone receptor PPARβ/δ is known to control mouse cutaneous repair and UV-induced skin cancer development. Here, we describe a novel PPARβ/δ-dependent molecular cascade involving TGFβ1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. We establish that the passenger miRNA miR-21-3p, that we identify as a novel UV-induced miRNA in the epidermis, plays a pro-inflammatory function in keratinocytes and that its high level of expression in human skin is associated with psoriasis and squamous cell carcinomas. Finally, we provide evidence that inhibition of miR-21-3p reduces UV-induced cutaneous inflammation in ex vivo human skin biopsies, thereby underlining the clinical relevance of miRNA-based topical therapies for cutaneous disorders.
Keywords
inflammation, miRNA, PPAR beta/delta, skin, therapeutics
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2016 9:36
Last modification date
20/08/2019 17:14
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