Weaker ligands can dominate an odor blend due to syntopic interactions.

Details

Ressource 1Download: BIB_EBF59C4B0332.P001.pdf (3601.55 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_EBF59C4B0332
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Weaker ligands can dominate an odor blend due to syntopic interactions.
Journal
Chemical Senses
Author(s)
Münch D., Schmeichel B., Silbering A.F., Galizia C.G.
ISSN
1464-3553 (Electronic)
ISSN-L
0379-864X
Publication state
Published
Issued date
2013
Volume
38
Number
4
Pages
293-304
Language
english
Abstract
Most odors in natural environments are mixtures of several compounds. Perceptually, these can blend into a new "perfume," or some components may dominate as elements of the mixture. In order to understand such mixture interactions, it is necessary to study the events at the olfactory periphery, down to the level of single-odorant receptor cells. Does a strong ligand present at a low concentration outweigh the effect of weak ligands present at high concentrations? We used the fruit fly receptor dOr22a and a banana-like odor mixture as a model system. We show that an intermediate ligand at an intermediate concentration alone elicits the neuron's blend response, despite the presence of both weaker ligands at higher concentration, and of better ligands at lower concentration in the mixture. Because all of these components, when given alone, elicited significant responses, this reveals specific mixture processing already at the periphery. By measuring complete dose-response curves we show that these mixture effects can be fully explained by a model of syntopic interaction at a single-receptor binding site. Our data have important implications for how odor mixtures are processed in general, and what preprocessing occurs before the information reaches the brain.
Keywords
Drosophila melanogaster, mixture interaction, mixture processing, olfaction, olfactory receptor neuron, Or22a
Pubmed
Web of science
Open Access
Yes
Create date
30/05/2013 13:14
Last modification date
20/08/2019 16:14
Usage data