CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_EBF3BB5349A2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.
Journal
iScience
Author(s)
Ji H., Chen Y., Castillo-Armengol J., Dreos R., Moret C., Niederhäuser G., Delacuisine B., Lopez-Mejia I.C., Denechaud P.D., Fajas L.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
26/06/2020
Peer-reviewed
Oui
Volume
23
Number
6
Pages
101163
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7 <sup>bKO</sup> ) have decreased BAT mass and impaired β3-adrenergic signaling and develop hypothermia upon cold exposure. We found that loss of CDK7 in BAT disrupts the induction of thermogenic genes in response to cold. However, Cdk7 <sup>bKO</sup> mice do not show systemic metabolic dysfunction. Increased expression of genes of the creatine metabolism compensates for the heat generation in the BAT of Cdk7 <sup>bKO</sup> mice in response to cold. Finally, we show that CDK7 is required for beta 3-adrenergic agonist-induced browning of white adipose tissue (WAT). Indeed, Cdk7 ablation in all adipose tissues (Cdk7 <sup>aKO</sup> ) has impaired browning in WAT. Together, our results demonstrate that CDK7 is an important mediator of beta-adrenergic signaling in thermogenic brown and beige fat.
Keywords
Biological Sciences, Cell Biology, Endocrinology
Pubmed
Web of science
Open Access
Yes
Create date
31/07/2020 13:15
Last modification date
01/08/2020 6:26
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