Do micronutrient deficiencies contribute to mitochondrial failure in critical illness?

Details

Serval ID
serval:BIB_EBEE32D2C128
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Do micronutrient deficiencies contribute to mitochondrial failure in critical illness?
Journal
Current opinion in clinical nutrition and metabolic care
Author(s)
Berger M.M.
ISSN
1473-6519 (Electronic)
ISSN-L
1363-1950
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
23
Number
2
Pages
102-110
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Mitochondrial dysfunction seems to be the common denominator of several critical care conditions and particularly of sepsis. Faced with relative failure, and limited progress of sepsis therapies aiming at blocking some oxidative and/or inflammatory pathways, the question of antioxidants micronutrient therapy, particularly of selenium, ascorbic acid and thiamine remains open.
The rationale for the essentiality of numerous micronutrients within the mitochondria is well established. Many studies have tested single micronutrients in animal and in-vitro models and provide positive evidences in favor of reduction of organ failure (cardiac and renal mainly). In clinical settings, high-dose selenium administration in sepsis has been disappointing. The most recent high dose, short-term ascorbic acid trial in sepsis is promising though, with an associated reduction of mortality, but analysis of the impact of this intervention on the various organs remains to be conducted.
Results from animal and human studies indicate that there are indeed intervention options at the level of the mitochondria, but neither the optimal dose nor the optimal combination of micronutrients is yet identified.
Keywords
Animals, Antioxidants/therapeutic use, Ascorbic Acid/therapeutic use, Critical Care/methods, Critical Care Outcomes, Critical Illness/therapy, Humans, Micronutrients/deficiency, Micronutrients/therapeutic use, Mitochondria/drug effects, Nutrition Therapy/methods, Oxidative Stress/drug effects, Selenium/therapeutic use, Sepsis/complications, Sepsis/therapy, Thiamine/therapeutic use
Pubmed
Web of science
Create date
29/01/2020 17:53
Last modification date
17/02/2024 8:12
Usage data