Weight of epidemiological evidence for titanium dioxide risk assessment: current state and further needs.

Details

Serval ID
serval:BIB_EBED760048C5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Weight of epidemiological evidence for titanium dioxide risk assessment: current state and further needs.
Journal
Journal of exposure science & environmental epidemiology
Author(s)
Guseva Canu I., Fraize-Frontier S., Michel C., Charles S.
ISSN
1559-064X (Electronic)
ISSN-L
1559-0631
Publication state
Published
Issued date
05/2020
Peer-reviewed
Oui
Volume
30
Number
3
Pages
430-435
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
We address here the importance of epidemiological evidence in risk assessment and decision-making in Europe. To illustrate this, titanium dioxide (TiO <sub>2</sub> ) was used as a model compound. TiO <sub>2</sub> is widely used as an odorless white pigment and opacifying agent. A recent systematic review assessing the weight of evidence on the relationship between exposure to TiO <sub>2</sub> (all forms) and cancer in humans questions the assumptions that TiO <sub>2</sub> is an inert material of low toxicity. Based on this new data, France submitted a proposal to classify TiO <sub>2</sub> as a possible human carcinogen under the European regulation. The European Chemicals Agency Risk assessment committee concluded that TiO <sub>2</sub> (all forms) warrants a classification as a suspected human carcinogen via inhalation (Category-2) under the CLP regulation (for Classification, Labeling and Packaging of chemicals). No considerations was given to TiO <sub>2</sub> particle size, which may affect human health effects. Consequently, further epidemiological studies are needed to assess possible associations between different physical-chemical characteristics of TiO <sub>2</sub> exposures and their impact on human health. This would allow strengthening the evidence on which to build the most appropriate regulation and to guaranty safe use given any exposure route of any TiO <sub>2</sub> particle shape or size.
Keywords
Bias, Lung cancer, Nanoparticle, Occupational exposure, Policy, Systematic review
Pubmed
Web of science
Create date
11/09/2019 14:14
Last modification date
13/06/2020 6:20
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