Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease.

Details

Serval ID
serval:BIB_EBEA94A25512
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease.
Journal
Human Pathology
Author(s)
Bouzourene H., Chaubert P., Seelentag W., Bosman F.T., Saraga E.
ISSN
0046-8177 (Print)
ISSN-L
0046-8177
Publication state
Published
Issued date
1999
Volume
30
Number
1
Pages
66-71
Language
english
Abstract
Aberrant crypt foci (ACF) are putative preneoplastic lesions that might represent the earliest morphological lesion visible in colonic carcinogenesis. However, findings concerning the growth and morphological features of these lesions in human studies suggest that ACF are highly heterogeneous in nature. In this study, we evaluated the morphological features of a large number of ACF in colon mucosa of 26 patients with colorectal carcinoma (CRC), four patients with adenoma as well as seven patients with nonneoplastic colonic diseases. By dissecting microscope, 508 ACF were identified, and of these, 378 were sampled for histological examination. The median ACF density (number of ACF/cm2) was significantly higher in the left colon than in the right colon (0.047 v 0.014 ACF/cm2). Unexpectedly, in our series, the overall ACF density was higher in the nonneoplastic colonic diseases than in CRC (0.13 v 0.032 ACF/cm2, P=.0087), cases of nonneoplastic diseases, however, being limited to 7 patients. ACF were significantly larger in colons with CRC or adenoma than in colons with nonneoplastic disease (P < .03). On histological examination, we observed 133 ACF with normal epithelium, 189 ACF with hyperplasia, 27 ACF with atypical hyperplasia, and 29 ACF with dysplasia. We noted a progressive increase of median ACF size from normal mucosa to hyperplasia, atypical hyperplasia, and dysplasia. Dysplastic ACF were more frequently observed in patients with CRC or adenoma and showed predominantly elongated crypt orifices (P < .0001). We conclude that ACF are histologically heterogeneous, encompass a spectrum of lesions of which only a subset are associated with dysplasia and then represent an early step in colorectal carcinogenesis. ACF with dysplasia are characterized by larger size, elongated crypt orifices, and an association with CRC.
Keywords
Adenocarcinoma/pathology, Adenocarcinoma/surgery, Adenoma/pathology, Adenoma/surgery, Adult, Aged, Aged, 80 and over, Colon/pathology, Colon/surgery, Colorectal Neoplasms/pathology, Colorectal Neoplasms/surgery, Female, Humans, Hyperplasia/pathology, Intestinal Mucosa/pathology, Intestinal Mucosa/surgery, Male, Middle Aged, Precancerous Conditions/pathology
Pubmed
Web of science
Create date
02/09/2011 18:12
Last modification date
20/08/2019 16:14
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