Revisiting sodium and water reabsorption with functional genomics tools.

Details

Serval ID
serval:BIB_EBCFA1A4F4E2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Revisiting sodium and water reabsorption with functional genomics tools.
Journal
Current Opinion in Nephrology and Hypertension
Author(s)
Firsov D.
ISSN
1062-4821 (Print)
ISSN-L
1062-4821
Publication state
Published
Issued date
2004
Volume
13
Number
1
Pages
59-65
Language
english
Abstract
PURPOSE OF REVIEW: The kidney plays an essential role in maintaining sodium and water balance, thereby controlling the volume and osmolarity of the extracellular body fluids, the blood volume and the blood pressure. The final adjustment of sodium and water reabsorption in the kidney takes place in cells of the distal part of the nephron in which a set of apical and basolateral transporters participate in vectorial sodium and water transport from the tubular lumen to the interstitium and, finally, to the general circulation. According to a current model, the activity and/or cell-surface expression of these transporters is/are under the control of a gene network composed of the hormonally regulated, as well as constitutively expressed, genes. It is proposed that this gene network may include new candidate genes for salt- and water-losing syndromes and for salt-sensitive hypertension. A new generation of functional genomics techniques have recently been applied to the characterization of this gene network. The purpose of this review is to summarize these studies and to discuss the potential of the different techniques for characterization of the renal transcriptome.
RECENT FINDINGS: Recently, DNA microarrays and serial analysis of gene expression have been applied to characterize the kidney transcriptome in different in-vivo and in-vitro models. In these studies, a set of new interesting genes potentially involved in the regulation of sodium and water reabsorption by the kidney have been identified and are currently under detailed investigation.
SUMMARY: Characterization of the kidney transcriptome is greatly expanding our knowledge of the gene networks involved in multiple kidney functions, including the maintenance of sodium and water homeostasis.
Keywords
Aldosterone/genetics, Animals, Computational Biology, Gene Expression Regulation/physiology, Genomics, Humans, Kidney/metabolism, Oligonucleotide Array Sequence Analysis, Sodium/metabolism, Vasopressins/genetics, Water/metabolism
Pubmed
Web of science
Create date
24/01/2008 12:32
Last modification date
20/08/2019 16:14
Usage data