The initial prodrome to bipolar affective disorder: prospective case studies.

Details

Serval ID
serval:BIB_EBCAB40D319F
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
The initial prodrome to bipolar affective disorder: prospective case studies.
Journal
Journal of affective disorders
Author(s)
Thompson K.N., Conus P.O., Ward J.L., Phillips L.J., Koutsogiannis J., Leicester S., McGorry P.D.
ISSN
0165-0327 (Print)
ISSN-L
0165-0327
Publication state
Published
Issued date
10/2003
Peer-reviewed
Oui
Volume
77
Number
1
Pages
79-85
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The initial prodrome to bipolar disorder has received very little attention to date, with most of the available data only addressing the prodrome to relapse. This study presents several prospective case studies of the initial prodrome to bipolar affective disorder.
Three patients are presented who developed bipolar disorder during their treatment at the Personal Assessment and Crisis Evaluation Clinic (PACE). They were prospectively interviewed over a 12-month period using standard clinical research interviews.
These patients met the criteria for bipolar disorder by the end of the treatment period. Depressive symptoms were the main reason for their first clinical presentation, with mania developing at a later date. Other comorbidities were observed before they were diagnosed with bipolar disorder.
The generalisability of our findings was constrained because of the small sample size. Furthermore, our findings are likely to be influenced by the intake criteria used at PACE, a clinic that primarily aims at identifying patients at risk of psychosis rather than bipolar disorder.
Our study provides information about the initial prodrome to bipolar disorder, which has previously been neglected in research studies. We found there were no prodrome features that clearly distinguished between patients who go on to develop bipolar disorder and those who develop schizophrenia. We hope our prospective data will be the starting point for subsequent studies, with the aim of applying these findings to developing suitable preventative interventions for bipolar disorder.

Keywords
Adolescent, Adult, Bipolar Disorder/diagnosis, Bipolar Disorder/psychology, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Prospective Studies, Severity of Illness Index
Pubmed
Web of science
Create date
10/03/2008 9:59
Last modification date
20/08/2019 16:13
Usage data