Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers

Details

Serval ID
serval:BIB_EBAF1B5D0D89
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers
Journal
Radiology
Author(s)
Terrier  F., Vock  P., Cotting  J., Ladebeck  R., Reichen  J., Hentschel  D.
ISSN
0033-8419 (Print)
Publication state
Published
Issued date
05/1989
Volume
171
Number
2
Pages
557-63
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
Dynamic phosphorus-31 magnetic resonance (MR) spectroscopy of the liver after intravenous administration of fructose has been suggested as a test of liver function. To establish dose-response curves of the phosphorus metabolites in the normal human liver, each of four healthy volunteers was given two to four different fructose doses on separate days: 62.5, 125, 250, 375, or 500 mg per kilogram of body weight. P-31 MR spectra of the liver were acquired with a 2-T whole-body magnetic, both before and after fructose administration, at 2.5-minute intervals over at least 30 minutes. The fructose load caused a significant, linearly dose-dependent accumulation of phosphomonoesters (r = .72, P less than .01) and a decrease in inorganic phosphate (r = .78, P less than .005) and adenosine triphosphate (r = .73, P less than .01). On the basis of these experiments, dynamic P-31 MR spectroscopy seems promising in the assessment of liver function.
Keywords
Adult Dose-Response Relationship, Drug Fructose/administration & dosage/*diagnostic use Humans Liver/*anatomy & histology Liver Function Tests/*methods *Magnetic Resonance Spectroscopy Male
Pubmed
Web of science
Create date
24/01/2008 16:41
Last modification date
20/08/2019 16:13
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