Energy Loss Index and Dimensionless Index Outperform Direct Valve Planimetry in Low-Gradient Aortic Stenosis.
Details
Serval ID
serval:BIB_EB08FBEDC7A1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Energy Loss Index and Dimensionless Index Outperform Direct Valve Planimetry in Low-Gradient Aortic Stenosis.
Journal
Journal of clinical medicine
ISSN
2077-0383 (Print)
ISSN-L
2077-0383
Publication state
Published
Issued date
30/05/2024
Peer-reviewed
Oui
Volume
13
Number
11
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Background/Objectives: Among patients with suspected severe aortic stenosis (AS), discordance between effective orifice area (EOA) and transvalvular gradients is frequent and requires a multiparametric workup including flow assessment and calcium-scoring to confirm true severe AS. The aim of this study was to assess direct planimetry, energy loss index (Eli) and dimensionless index (DI) as stand-alone parameters to identify non-severe AS in discordant cases. Methods: In this prospective cohort study, we included consecutive AS patients > 70 years with EOA < 1.0 cm <sup>2</sup> referred for valve replacement between 2014 and 2017. AS severity was retrospectively reassessed using the multiparametric work-up recommended in the 2021 ESC/EACTS guidelines. DI and ELi were calculated, and valve area was measured by direct planimetry on transesophageal echocardiography. Results: A total of 101 patients (mean age 82 y; 57% male) were included. Discordance between EOA and gradients was observed in 46% and non-severe AS found in 24% despite an EOA < 1 cm <sup>2</sup> . Valve planimetry performed poorly, with an area under the ROC curve (AUC) of 0.64. At a cut-off value of >0.82 cm <sup>2</sup> , sensitivity and specificity to identify non-severe AS were 67 and 66%, respectively. DI and ELi showed a higher diagnostic accuracy, with an AUC of 0.77 and 0.76, respectively. Cut-off values of >0.24 and >0.6 cm <sup>2</sup> /m <sup>2</sup> identified non-severe AS, with a high specificity of 79% and 91%, respectively. Conclusions: Almost one in four patients with EOA < 1 cm <sup>2</sup> had non-severe AS according to guideline-recommended multiparametric assessment. Direct valve planimetry revealed poor diagnostic accuracy and should be interpreted with caution. Usual prognostic cut-off values for DI > 0.24 and ELI > 0.6 cm <sup>2</sup> /m <sup>2</sup> identified non-severe AS with high specificity and should therefore be included in the assessment of low-gradient AS.
Keywords
dimensionless index, echocardiography, energy loss index, low-gradient aortic stenosis, multiparametric assessment
Pubmed
Web of science
Open Access
Yes
Create date
21/06/2024 9:31
Last modification date
26/07/2024 7:01