Cross-reactive immunity potentially drives global oscillation and opposed alternation patterns of seasonal influenza A viruses.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_EAB9B345286E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cross-reactive immunity potentially drives global oscillation and opposed alternation patterns of seasonal influenza A viruses.
Journal
Scientific reports
Author(s)
Gatti L., Koenen M.H., Zhang J.D., Anisimova M., Verhagen L.M., Schutten M., Osterhaus A., van der Vries E.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
25/05/2022
Peer-reviewed
Oui
Volume
12
Number
1
Pages
8883
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Several human pathogens exhibit distinct patterns of seasonality and circulate as pairs. For instance, influenza A virus subtypes oscillate and peak during winter seasons of the world's temperate climate zones. Alternation of dominant strains in successive influenza seasons makes epidemic forecasting a major challenge. From the start of the 2009 influenza pandemic we enrolled influenza A virus infected patients (n = 2980) in a global prospective clinical study. Complete hemagglutinin sequences were obtained from 1078 A/H1N1 and 1033 A/H3N2 viruses. We used phylodynamics to construct high resolution spatio-temporal phylogenetic hemagglutinin trees and estimated global influenza A effective reproductive numbers (R) over time (2009-2013). We demonstrate that R oscillates around R = 1 with a clear opposed alternation pattern between phases of the A/H1N1 and A/H3N2 subtypes. Moreover, we find a similar alternation pattern for the number of global viral spread between the sampled geographical locations. Both observations suggest a between-strain competition for susceptible hosts on a global level. Extrinsic factors that affect person-to-person transmission are a major driver of influenza seasonality. The data presented here indicate that cross-reactive host immunity is also a key intrinsic driver of influenza seasonality, which determines the influenza A virus strain at the onset of each epidemic season.
Keywords
Hemagglutinins, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype/genetics, Influenza A virus, Influenza, Human/epidemiology, Phylogeny, Prospective Studies, Seasons
Pubmed
Web of science
Open Access
Yes
Create date
17/06/2022 13:29
Last modification date
23/01/2024 7:36
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