PPARs at the crossroads of lipid signaling and inflammation.

Details

Serval ID
serval:BIB_EA74394CACCD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
PPARs at the crossroads of lipid signaling and inflammation.
Journal
Trends in Endocrinology and Metabolism
Author(s)
Wahli W., Michalik L.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Publication state
Published
Issued date
2012
Volume
23
Number
7
Pages
351-363
Language
english
Abstract
Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects genes controlling vital processes. Among them, the peroxisome proliferator-activated receptors (PPARs) have emerged as links between lipids, metabolic diseases, and innate immunity. PPARs are activated by fatty acids and their derivatives, many of which also signal through membrane receptors, thereby creating a lipid signaling network between the cell surface and the nucleus. Tissues that play a role in whole-body metabolic homeostasis, such as adipose tissue, liver, skeletal muscle, intestines, and blood vessel walls, are prone to inflammation when metabolism is disturbed, a complication that promotes type 2 diabetes and cardiovascular disease. This review discusses the protective roles of PPARs in inflammatory conditions and the therapeutic anti-inflammatory potential of PPAR ligands.
Pubmed
Web of science
Create date
27/08/2012 18:36
Last modification date
20/08/2019 17:12
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