Sleep modulates haematopoiesis and protects against atherosclerosis.

Details

Serval ID
serval:BIB_EA729FDF734C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sleep modulates haematopoiesis and protects against atherosclerosis.
Journal
Nature
Author(s)
McAlpine C.S., Kiss M.G., Rattik S., He S., Vassalli A., Valet C., Anzai A., Chan C.T., Mindur J.E., Kahles F., Poller W.C., Frodermann V., Fenn A.M., Gregory A.F., Halle L., Iwamoto Y., Hoyer F.F., Binder C.J., Libby P., Tafti M., Scammell T.E., Nahrendorf M., Swirski F.K.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
02/2019
Peer-reviewed
Oui
Volume
566
Number
7744
Pages
383-387
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Sleep is integral to life <sup>1</sup> . Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease <sup>2</sup> , we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6C <sup>high</sup> monocytes, develop larger atherosclerotic lesions and produce less hypocretin-a stimulatory and wake-promoting neuropeptide-in the lateral hypothalamus. Hypocretin controls myelopoiesis by restricting the production of CSF1 by hypocretin-receptor-expressing pre-neutrophils in the bone marrow. Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atherosclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementation have reduced numbers of circulating monocytes and smaller atherosclerotic lesions. Together, these results identify a neuro-immune axis that links sleep to haematopoiesis and atherosclerosis.
Keywords
Animals, Antigens, Ly/metabolism, Atherosclerosis/metabolism, Atherosclerosis/pathology, Atherosclerosis/prevention & control, Bone Marrow Cells/metabolism, Female, Hematopoiesis/drug effects, Hematopoiesis/physiology, Hypothalamic Area, Lateral/metabolism, Male, Mice, Monocytes/drug effects, Monocytes/metabolism, Myelopoiesis/drug effects, Neutrophils/metabolism, Orexin Receptors/deficiency, Orexin Receptors/metabolism, Orexins/biosynthesis, Orexins/deficiency, Orexins/metabolism, Orexins/pharmacology, Sleep/drug effects, Sleep/physiology, Sleep Deprivation/metabolism, Sleep Deprivation/physiopathology, Sleep Deprivation/prevention & control
Pubmed
Web of science
Create date
11/03/2019 17:21
Last modification date
21/08/2019 5:33
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