Skull base chordomas: presentation of six cases and review of the literature.
Details
Serval ID
serval:BIB_EA51ED2DB141
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Skull base chordomas: presentation of six cases and review of the literature.
Journal
Journal of Clinical Neuroscience
ISSN
0967-5868
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
1
Number
1
Pages
7-18
Language
english
Abstract
Chordomas are uncommon tumours occuring from remnants of the notochord. They are mainly localized in the sacrococcygium, the spine and the skull base. We focused our study on skull base chordomas and reviewed 531 published cases and 6 cases diagnosed in our institution. The six cases diagnosed at our hospital are described with a special mention of a unique case presenting with meningitis. Clinical features, radiology, histopathology and survival with different treatments are reviewed. Skull base chordomas can occur at any age and are slightly more frequent in males. Patients complain most often of diplopia and headaches. Abducens nerve palsy is the commonest neurological finding. Radiological examination should include both CT-scan which shows extensive osteolysis, calcifications and contrast enhancement and MRI for topographical definition. Metastases rarely occur. Treatment remains controversial but combined surgery and radiotherapy is the best treatment with a 5 year survival rate of 75%.
Pubmed
Web of science
Create date
24/03/2009 9:20
Last modification date
20/08/2019 17:12