Effects of circadian rhythm disruption on retinal physiopathology: Considerations from a consensus of experts.
Details
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_EA433738B534
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Effects of circadian rhythm disruption on retinal physiopathology: Considerations from a consensus of experts.
Journal
European journal of ophthalmology
ISSN
1724-6016 (Electronic)
ISSN-L
1120-6721
Publication state
Published
Issued date
09/2022
Peer-reviewed
Oui
Volume
32
Number
5
Pages
2489-2493
Language
english
Notes
Publication types: Editorial
Publication Status: ppublish
Publication Status: ppublish
Abstract
The circadian rhythms originate within the organism and synchronize with cyclic fluctuations in the external environment. It has been demonstrated that part of the human genome is under control of the circadian clock and that a synchronizer that helps to maintain daily rhythms is Melatonin, a neuro-hormone primarily synthesized by the pineal gland during the night. The chronic disruption of circadian rhythm has been linked to many conditions such as obesity, metabolic syndrome, type 2 diabetes, cancer, and neurodegenerative diseases. Studies in the mice showed that the disruption of the retinal circadian rhythm increases the decline during the aging of photoreceptors, accelerating age-related disruption of cone cell structure, function, and viability and that the melatonin receptor deletion seems to influence the health of retinal cells, speeding up their aging. In conclusion, preserving the circadian rhythms could be to add to the prevention and treatment of age-related degenerative retinal diseases, and although additional studies are needed, melatonin could be a valid support to favor this "chronoprotection action".
Keywords
Animals, Circadian Rhythm/physiology, Consensus, Diabetes Mellitus, Type 2/metabolism, Humans, Melatonin/metabolism, Melatonin/pharmacology, Mice, Retina/physiology, Circadian rhythm, age related macular degeneration, chronoprotection, melatonin
Pubmed
Web of science
Open Access
Yes
Create date
24/06/2022 18:13
Last modification date
25/01/2024 8:46