Multidisciplinary treatment approach to locally advanced non-inflammatory breast cancer using chemotherapy and radiotherapy with or without surgery
Details
Serval ID
serval:BIB_EA3B14B5D865
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multidisciplinary treatment approach to locally advanced non-inflammatory breast cancer using chemotherapy and radiotherapy with or without surgery
Journal
Radiotherapy and Oncology
ISSN
0167-8140
Publication state
Published
Issued date
11/1992
Peer-reviewed
Oui
Volume
25
Number
3
Pages
167-75
Notes
Journal Article --- Old month value: Nov
Abstract
Between April 1982 and December 1987, 82 locally advanced non-metastatic and non-inflammatory breast cancers were treated (42 stage IIIA, 40 stage IIIB). The median follow-up is 70 months from the beginning of the treatment. The initial treatment consisted of 4 courses of chemotherapy (doxorubicin, vincristine, cyclophosphamide, 5-fluorouracil) followed by irradiation (45 Gy to the breast and nodal area). A fifth course of chemotherapy was given after radiation therapy. Three different locoregional approaches were proposed depending on the tumoral response. In 32 patients (39%) with residual tumor larger than 3 cm in diameter or located behind the nipple or with multifocal tumors, mastectomy and axillary dissection were performed. Fifty other patients (61%) benefited from conservative treatment: 32 patients (39%) achieved complete remission and received a boost to the initial tumor bed; 18 patients (22%) who had a residual mass less than or equal to 3 cm in diameter were treated by tumorectomy and axillary dissection followed by a boost to the tumorectomy site. After completion of local therapy, all patients received a sixth course of chemotherapy. A maintenance adjuvant chemotherapy regimen without anthracycline was prescribed (12 monthly cycles). Three- and 5-year disease-free survival rates were 81.7% and 72% respectively. Five-year locoregional relapse rate (with or without other sites of failure) was 8.8%. In a multivariate analysis, disease-free survival was significantly influenced by the N-stage (p < 0.0001), initial tumor size (p = 0.01), and tumor response after initial chemotherapy (p = 0.02). Five-year breast conservation probability was 58.4%.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Breast Neoplasms/mortality/pathology/*therapy
Combined Modality Therapy
Humans
Lymphatic Metastasis
Middle Aged
Neoplasm Recurrence, Local
Prognosis
Prospective Studies
Survival Rate
Pubmed
Web of science
Create date
24/01/2008 17:16
Last modification date
20/08/2019 16:12