The Impact of Caloric and Non-Caloric Sweeteners on Food Intake and Brain Responses to Food: A Randomized Crossover Controlled Trial in Healthy Humans.

Details

Serval ID
serval:BIB_E9F32B8693BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Impact of Caloric and Non-Caloric Sweeteners on Food Intake and Brain Responses to Food: A Randomized Crossover Controlled Trial in Healthy Humans.
Journal
Nutrients
Author(s)
Crézé C., Candal L., Cros J., Knebel J.F., Seyssel K., Stefanoni N., Schneiter P., Murray M.M., Tappy L., Toepel U.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
15/05/2018
Peer-reviewed
Oui
Volume
10
Number
5
Pages
NA
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: epublish
Abstract
Whether non-nutritive sweetener (NNS) consumption impacts food intake behavior in humans is still unclear. Discrepant sensory and metabolic signals are proposed to mislead brain regulatory centers, in turn promoting maladaptive food choices favoring weight gain. We aimed to assess whether ingestion of sucrose- and NNS-sweetened drinks would differently alter brain responses to food viewing and food intake. Eighteen normal-weight men were studied in a fasted condition and after consumption of a standardized meal accompanied by either a NNS-sweetened (NNS), or a sucrose-sweetened (SUC) drink, or water (WAT). Their brain responses to visual food cues were assessed by means of electroencephalography (EEG) before and 45 min after meal ingestion. Four hours after meal ingestion, spontaneous food intake was monitored during an ad libitum buffet. With WAT, meal intake led to increased neural activity in the dorsal prefrontal cortex and the insula, areas linked to cognitive control and interoception. With SUC, neural activity in the insula increased as well, but decreased in temporal regions linked to food categorization, and remained unchanged in dorsal prefrontal areas. The latter modulations were associated with a significantly lower total energy intake at buffet (mean kcal ± SEM; 791 ± 62) as compared to WAT (942 ± 71) and NNS (917 ± 70). In contrast to WAT and SUC, NNS consumption did not impact activity in the insula, but led to increased neural activity in ventrolateral prefrontal regions linked to the inhibition of reward. Total energy intake at the buffet was not significantly different between WAT and NNS. Our findings highlight the differential impact of caloric and non-caloric sweeteners on subsequent brain responses to visual food cues and energy intake. These variations may reflect an initial stage of adaptation to taste-calorie uncoupling, and could be indicative of longer-term consequences of repeated NNS consumption on food intake behavior.
Keywords
Beverages, Blood Glucose/metabolism, Body Composition, Body Mass Index, Brain/physiology, Choice Behavior, Cross-Over Studies, Diet, Double-Blind Method, Electroencephalography, Energy Intake, Food Preferences, Ghrelin/blood, Health Behavior, Humans, Hunger, Insulin/blood, Male, Non-Nutritive Sweeteners/administration & dosage, Nutritive Sweeteners/administration & dosage, Postprandial Period, Satiation, Taste, Weight Gain, ad libitum buffet, electroencephalography, food intake, non-nutritive sweeteners, sweet taste, visual food cues
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2018 18:18
Last modification date
20/08/2019 17:12
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