Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.

Details

Serval ID
serval:BIB_E9DD7C85A1F9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Poirel L., Kieffer N., Brink A., Coetze J., Jayol A., Nordmann P.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
60
Number
7
Pages
4394-4397
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
A series of colistin-resistant Escherichia coli clinical isolates was recovered from hospitalized and community patients in South Africa. Seven clonally unrelated isolates harbored the mcr-1 gene located on different plasmid backbones. Two distinct plasmids were fully sequenced, and identical 2,600-bp-long DNA sequences defining a mcr-1 cassette were identified. Promoter sequences responsible for the expression of mcr-1, deduced from the precise identification of the +1 transcription start site for mcr-1, were characterized.

Keywords
Anti-Bacterial Agents/pharmacology, Colistin/pharmacology, Drug Resistance, Bacterial/genetics, Escherichia coli/drug effects, Escherichia coli/genetics, Microbial Sensitivity Tests, Plasmids/genetics, South Africa, beta-Lactamases/genetics
Pubmed
Web of science
Open Access
Yes
Create date
05/10/2017 12:54
Last modification date
20/08/2019 16:12
Usage data