Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.

Details

Serval ID
serval:BIB_E9C5623E4908
Type
Article: article from journal or magazin.
Collection
Publications
Title
Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.
Journal
Human Pathology
Author(s)
La Rosa S., Inzani F., Vanoli A., Klersy C., Dainese L., Rindi G., Capella C., Bordi C., Solcia E.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
42
Number
10
Pages
1373-1384
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Gastric neuroendocrine neoplasms differ considerably in histology, clinicopathologic background, stage, and patient outcome, implying a wide spectrum of therapeutic options, hence the need for improved diagnostic and prognostic criteria to select appropriate therapy. Here, we tested the European NeuroEndocrine Tumor Society and the novel World Health Organization 2010 grade and stage classifications together with additional clinicopathologic and histologic parameters in a series of 209 gastric neuroendocrine neoplasms with a median follow-up of 89 months. Fifty-one grade 3 neuroendocrine carcinomas and 15 mixed endocrine-exocrine carcinomas of poor outcome were separated from 143 neuroendocrine tumors, including 132 G1 or G2 enterochromaffin-like (ECL) cell neoplasms and 11 G1 gastrin-cell, somatostatin-cell, or serotonin-cell tumors. Most G1 cases had excellent prognosis, even when metastatic, whereas G2 and G3 neoplasms had worse or very severe prognosis, respectively. The European NeuroEndocrine Tumor Society-World Health Organization 2010 proliferative grading system well correlated with patient survival. Structural histologic parameters were equally predictive and when combined with the European NeuroEndocrine Tumor Society-World Health Organization 2010 grading system in a "global grade" improved tumor prognostic stratification. The European NeuroEndocrine Tumor Society-World Health Organization 2010 staging system proved effective. Introduction of novel T (T(1a) and T(1b) or deep submucosal) and N categories (N(1), <3 nodes metastases; N(2), ≥3) allowed a simplified, equally informative 3-stage TNM system. Such improved diagnostic and prognostic criteria for gastric neuroendocrine neoplasms are proposed and discussed.
Keywords
Carcinoma, Neuroendocrine/diagnosis, Carcinoma, Neuroendocrine/pathology, Humans, Neoplasm Staging, Neoplasms, Complex and Mixed/diagnosis, Neoplasms, Complex and Mixed/pathology, Neuroendocrine Tumors/diagnosis, Neuroendocrine Tumors/pathology, Prognosis, Stomach Neoplasms/diagnosis, Stomach Neoplasms/pathology
Pubmed
Web of science
Create date
06/09/2016 13:23
Last modification date
20/08/2019 16:12
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