Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family.

Details

Serval ID
serval:BIB_E9A8F86F645C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family.
Journal
Journal of Molecular Evolution
Author(s)
Haefliger D.N., Moskaitis J.E., Schoenberg D.R., Wahli W.
ISSN
0022-2844
Publication state
Published
Issued date
10/1989
Peer-reviewed
Oui
Volume
29
Number
4
Pages
344-354
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Abstract
The Xenopus laevis 68-kd and 74-kd albumin amino acid sequences are examined with respect to their relationship to the other known members of the albumin/alpha-fetoprotein/vitamin D-binding protein gene family. Each of the three members of this family presents a unique pattern of conserved regions indicating a differential selective pressure related to specific functional characteristics. Furthermore, an evolutionary tree of these genes was deduced from the divergence times calculated from direct nucleotide sequence comparisons of individual gene pairs. These calculations indicate that the vitamin D-binding protein/albumin separation occurred 560-600 million years (Myr) ago and the albumin/alpha-fetoprotein divergence 280 Myr ago. This observation leads to the hypothesis according to which the albumin/alpha-fetoprotein gene duplication occurred shortly after the amphibian/reptile separation. Consequently, and unlike mammals, amphibians and fishes should lack an alpha-fetoprotein in their serum at larval stages, which is consistent with a recent analysis of serum proteins in Xenopus laevis larvae. This hypothesis now will have to be tested further in additional lower vertebrates.
Keywords
Albumins/genetics, Amino Acid Sequence, Animals, Base Sequence, Genes, Molecular Sequence Data, Multigene Family, Phylogeny, Sequence Homology, Nucleic Acid, Vertebrates/genetics, Vitamin D-Binding Protein/genetics, Xenopus laevis/genetics, alpha-Fetoproteins/genetics
Pubmed
Web of science
Create date
24/01/2008 16:05
Last modification date
20/08/2019 16:12
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