Opiate modulation of the pituitary-adrenal axis: effects of stress and circadian rhythm

Details

Serval ID
serval:BIB_E992C5DFAAE9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Opiate modulation of the pituitary-adrenal axis: effects of stress and circadian rhythm
Journal
Clinical Endocrinology
Author(s)
Grossman  A., Gaillard  R. C., McCartney  P., Rees  L. H., Besser  G. M.
ISSN
0300-0664 (Print)
Publication state
Published
Issued date
09/1982
Volume
17
Number
3
Pages
279-86
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
The opiate control of the pituitary-adrenal axis has been investigated in normal subjects. The infusion of 1 mg of the met-enkephalin analogue, DAMME, led to a fall in circulating cortisol in spite of a fall in blood pressure. Conversley, 16 mg of the opiate antagonist, naloxone led to brisk and pronounced elevations in plasma ACTH, lipotrophin (LPH) and cortisol. The rise above basal levels was consistent, irrespective of whether the infusion was given at 09.00, 18.00, or 23.00 h; the peak response obtained was significantly less at 23.00 h than at either 09.00 or 18.00 h. Finally, insulin-induced hypoglycaemia (0.15 u/kg) or naloxone (25 mg) produced a similar rise in plasma cortisol which was no different when the two stimuli were combined. It is suggested that there is a constant tonic inhibition of the pituitary-adrenal axis by endogenous opiates throughout 24 h, and that the circadian rhythm of ACTH/LPH secretion is not due to changes in opiate tone. However, disinhibition of this tone is likely to be responsible, at least in part, for the rise in cortisol in response to hypoglycaemic stress.
Keywords
Adolescent Adrenocorticotropic Hormone/blood Adult Blood Pressure/drug effects *Circadian Rhythm D-Ala(2),MePhe(4),Met(0)-ol-enkephalin Enkephalin, Methionine/analogs & derivatives/pharmacology Female Humans Hydrocortisone/blood Hypoglycemia/physiopathology Male Naloxone/pharmacology Narcotics/*pharmacology Pituitary-Adrenal System/*drug effects/physiopathology Stress/*physiopathology
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 16:12
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