Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man.

Details

Serval ID
serval:BIB_E9836251C25C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man.
Journal
Clinical Science
Author(s)
Nussberger J., Brunner D.B., Waeber B., Biollaz J., Brunner H.R.
ISSN
0143-5221 (Print)
ISSN-L
0143-5221
Publication state
Published
Issued date
1987
Peer-reviewed
Oui
Volume
72
Number
3
Pages
387-389
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.
Keywords
Adult, Angiotensin I/blood, Angiotensin-Converting Enzyme Inhibitors, Enalapril/analogs & derivatives, Enalapril/pharmacology, Humans, Lisinopril, Male, Renin/blood
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 16:12
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