Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool

Details

Serval ID
serval:BIB_E9721D52C127
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Accolla  R. S., Gross  N., Carrel  S., Corte  G.
ISSN
0027-8424
Publication state
Published
Issued date
07/1981
Peer-reviewed
Oui
Volume
78
Number
7
Pages
4549-51
Notes
Journal Article --- Old month value: Jul
Abstract
Two distinct subsets of human Ia molecules, called NG1 and NG2, present in all individuals irrespective of their HLA-DR phenotype, which were previously defined by their reactivity with two monoclonal hybridoma antibodies, D1--12 and D4--22, were analyzed by two-dimensional peptide mapping techniques. Results show that, in the Ia molecular pool from a single individual, small beta subunits of the NG1 and NG2 subsets display significant differences from each other. In addition, beta subunits of the same subset from two different allotype Ia molecular pools are also different from each other, thus indicating that NG1 and NG2 subsets carry polymorphic specificities. Moreover, large alpha chains of NG1 and NG2 subsets are different from each other; however, no significant differences are observed in alpha chains of the same subset when different allotype Ia pools are analyzed. The possible genetic implications of these findings are discussed.
Keywords
Antibodies, Monoclonal/immunology Chromatography, Affinity Genes *Histocompatibility Antigens Class II/genetics/isolation & purification Humans Macromolecular Substances Polymorphism, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2008 15:55
Last modification date
20/08/2019 16:12
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