Radiofrequency ablation versus surgical resection for hepatocellular carcinoma within the Milan criteria: A study of 281 Western patients.

Details

Serval ID
serval:BIB_E9603E7383E5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Radiofrequency ablation versus surgical resection for hepatocellular carcinoma within the Milan criteria: A study of 281 Western patients.
Journal
International journal of hyperthermia
Author(s)
Hocquelet A., Balageas P., Laurent C., Blanc J.F., Frulio N., Salut C., Cassinotto C., Saric J., Possenti L., Bernard P.H., Montaudon M., Trillaud H.
ISSN
1464-5157 (Electronic)
ISSN-L
0265-6736
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
31
Number
7
Pages
749-757
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The aim of this study was to compare survival between radiofrequency ablation (RFA) and surgical resection (SR) in patients with hepatocellular carcinoma (HCC) within Milan criteria.
From January 2004 to December 2013 we consecutively and retrospectively included all patients with first occurrence of HCC within Milan criteria receiving SR or RFA as first-line treatment. The cumulative overall survival (OS) and disease-free survival (DFS) were compared after inverse probability weighting (including confounding factor).
A total of 281 patients (RFA 178, SR 103) were enrolled. In multivariate Cox regression RFA and SR were not independent predictors of survival or recurrence. The respective weighted 5 years OS and DFS for patients with propensity scores between 0.1-0.9 in the SR and RFA groups were 54-33% and 60-16.9%, P = 0.695 and P = 0.426, respectively. Local tumour progression rate did not differ according to treatment (P = 0.523). Major complication rate was higher in the SR group, P = 0.001. Hospitalisation duration was lower in the RFA group (mean 2.19 days, range 2-7) than in the SR group (mean 10.2 days, range 3-30), P < 0.001.
This large Western study has shown that OS and DFS did not differ after RFA (using mainly multipolar devices) and SR, for HCC within the Milan criteria in a European population, with a shorter hospitalisation time and a lower complication rate for RFA.

Keywords
Aged, Carcinoma, Hepatocellular/pathology, Carcinoma, Hepatocellular/radiotherapy, Carcinoma, Hepatocellular/surgery, Disease Progression, Disease-Free Survival, Female, Humans, Liver Neoplasms/pathology, Liver Neoplasms/radiotherapy, Liver Neoplasms/surgery, Male, Middle Aged, Probability, Pulsed Radiofrequency Treatment, Retrospective Studies, Barcelona Clinic Liver Cancer (BCLC) stage, Milan criteria, hepatocellular carcinoma, radiofrequency ablation, surgical resection
Pubmed
Web of science
Create date
25/10/2017 13:29
Last modification date
20/08/2019 16:12
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