Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens.

Details

Serval ID
serval:BIB_E904ABCB0C27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens.
Journal
European journal of clinical microbiology & infectious diseases
Author(s)
Alvarez-Marin R., Aires-de-Sousa M., Nordmann P., Kieffer N., Poirel L.
ISSN
1435-4373 (Electronic)
ISSN-L
0934-9723
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
36
Number
12
Pages
2379-2383
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Multidrug-resistant (MR) Gram-negative (GN) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. Well-tolerated antiseptics, such as octenidine dihydrochloride (OCT), may be a very useful tool in infection control to reduce the dissemination of MRGN. This study aimed to investigate the bactericidal activity of OCT against international epidemic clones of MRGN. A set of five different species (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) was studied to prove OCT efficacy without organic load, under "clean conditions" (0.3 g/L albumin) and under "dirty conditions" (3 g/L albumin + 3 mL/L defibrinated sheep blood), according to an official test norm (EN13727). We used five clonally unrelated isolates per species, including a susceptible wild-type strain, and four MRGN isolates, corresponding to either the 3MRGN or 4MRGN definition of multidrug resistance. A contact time of 1 min was fully effective for all isolates by using different OCT concentrations (0.01% and 0.05%), with a bacterial reduction factor of >5 log <sub>10</sub> systematically observed. Growth kinetics were determined with two different wild-type strains (A. baumannii and K. pneumoniae), proving a time-dependent efficacy of OCT. These results highlight that OCT may be extremely useful to eradicate emerging highly resistant Gram-negative pathogens associated with nosocomial infections.
Keywords
Anti-Bacterial Agents/pharmacology, Anti-Infective Agents/pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Multiple, Bacterial/drug effects, Gram-Negative Bacteria/drug effects, Gram-Negative Bacteria/genetics, Gram-Negative Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Pyridines/pharmacology
Pubmed
Web of science
Create date
19/09/2017 13:43
Last modification date
20/08/2019 16:11
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