Pharmacokinetic and pharmacogenetic factors influencing methadone plasma levels

Details

Serval ID
serval:BIB_E8D5A9077B7E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pharmacokinetic and pharmacogenetic factors influencing methadone plasma levels
Journal
Heroin Addiction and Related Clinical Problems
Author(s)
Crettol Séverine, Eap Chin-Bin
ISSN
1592-1638
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
9
Number
2
Pages
39-46
Language
english
Notes
SAPHIRID:63946
Abstract
Methadone is widely used as a maintenance treatment for opiate addiction. Methadone plasma levels vary widely for a given dose, so contributing to interindividual variability in response to methadone maintenance treatment. Until recently, the relative in vivo involvement of various cytochrome P450 (CYP) isoforms in methadone pharmacokinetics had been unclear. A recent large-scale pharmacogenetic study with patients in methadone maintenance treatment has now demonstrated that CYP3A4 and CYP2B6 are the major cytochrome P450 isoforms with a major involvement in methadone metabolism, while CYP2D6 only contributes to a minor extent. In addition, P-glycoprotein, a transmembrane efflux protein, is also involved in methadone kinetics.
Create date
10/03/2008 10:54
Last modification date
20/08/2019 16:11
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