The oxidation-state-dependent ATP-binding site of cytochrome c. A possible physiological significance

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Serval ID
serval:BIB_E8CB47328168
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The oxidation-state-dependent ATP-binding site of cytochrome c. A possible physiological significance
Journal
Biochemical Journal
Author(s)
Corthesy  B. E., Wallace  C. J.
ISSN
0264-6021 (Print)
Publication state
Published
Issued date
06/1986
Volume
236
Number
2
Pages
359-64
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Abstract
Cytochrome c binds certain physiological anions that are known to modulate the biological properties of the protein, although it is not known whether this effect is fortuitous or has physiological significance. We have examined the ability of the protein and its semisynthetic analogues to associate with certain of these anions, e.g. ATP, ADP, Pi and citrate. Our results show that specific residues or clusters of residues on the surface of horse heart cytochrome c are involved in the recognition sites for these anions. We also observed that binding at one site is linked to the oxidation state of the protein.
Keywords
Adenosine Triphosphate/*metabolism Anions/metabolism Binding Sites Chromatography, Gel Cytochrome c Group/*metabolism Oxidation-Reduction
Pubmed
Web of science
Create date
25/01/2008 14:53
Last modification date
20/08/2019 16:11
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